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原著論文/Original Papers

  • Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M*.
    Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity.
    Proc Natl Acad Sci U S A 114, E3526-E3535 (2017)
    News Release
  • Tso CF, Simon T, Greenlaw AC, Puri T, Mieda M, Herzog ED.
    Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior.
    Curr Biol 27, 1055-1061 (2017)
  • Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R, Hida A, Tei H, Takeda S, Hinoi E.
    Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.
    J Bone Miner Res 32, 872-881 (2017)
  • Nakazato R, Hotta S, Yamada D, Kou M, Nakamura S, Takahata Y, Tei H, Numano R, Hida A, Shimba S, Mieda M, Hinoi E, Yoneda Y, Takarada T.
    The intrinsic microglial clock system regulates interleukin-6 expression.
    Glia 65, 198-208 (2017)
  • Mieda M*, Hasegawa E, Kessaris N, Sakurai T.
    Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain.
    Front Neurosci 11, 55 (2017)
  • Enoki R, Oda Y, Mieda M, Ono D, Honma S, Honma KI.
    Synchronous circadian voltage rhythms with asynchronous calcium rhythms in the suprachiasmatic nucleus.
    Proc Natl Acad Sci U S A 114, E2476-E2485 (2017)
  • Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T.
    QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.
    PLoS One 11, e0164716 (2016)
  • Mieda M*, Okamoto H, Sakurai T.
    Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period.
    Curr Biol 26, 2535-2542 (2016)
    News Release
  • Mieda M*, Ono D, Hasegawa E, Okamoto H, Honma K, Honma S, Sakurai T.
    Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm.
    Neuron 85, 1103-1116 (2015)
    News Release
  • Hasegawa E, Yanagisawa M, Sakurai T, Mieda M*.
    Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.
    J Clin Invest 124, 604-616 (2014)
    News Release
  • Masseck OA, Spoida K, Dalkara D, Maejima T, Rubelowski JM, Wallhorn L, Deneris ES, Herlitze S.
    Vertebrate cone opsins enable sustained and highly sensitive rapid control of Gi/o signaling in anxiety circuitry.
    Neuron 81, 1263-1273 (2014)
  • Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T.
    Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation.
    J Neurosci 33, 14549-14557 (2013)
  • Saito YC, Tsujino N, Hasegawa E, Akashi K, Abe M, Mieda M, Sakimura K, Sakurai T.
    GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons.
    Front Neural Circuits 7, 192 (2013)
  • Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T.
    Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states.
    PLoS One 8, e62391 (2013)
  • Maejima T, Wollenweber P, Teusner LU, Noebels JL, Herlitze S, Mark MD.
    Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice.
    J Neurosci 33, 5162-5174 (2013)
  • Maejima T, Masseck OA, Mark MD, Herlitze S.
    Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels.
    Front Integr Neurosci 7, 40 (2013)
  • Takarada T, Kodama A, Hotta S, Mieda M, Shimba S, Hinoi E, Yoneda Y.
    Clock genes influence gene expression in growth plate and endochondral ossification in mice.
    J Biol Chem 287, 36081-36095 (2012)
  • Sasaki K, Suzuki M, Mieda M*, Tsujino N, Roth B, Sakurai T*.
    Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice.
    PLoS One 6, e20360 (2011)
  • Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, Yamamoto M, Yanagisawa M, Sakurai T.
    Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory.
    PLoS One 6, e16972 (2011)
  • Mieda M*, Sakurai T.
    Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding.
    J Neurosci 31, 15391-15396 (2011)
  • Mieda M*, Hasegawa E, Kisanuki YY, Sinton CM, Yanagisawa M, Sakurai T*.
    Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep.
    J Neurosci 31, 6518-6526 (2011)
  • Mark MD, Maejima T, Kuckelsberg D, Yoo JW, Hyde RA, Shah V, Gutierrez D, Moreno RL, Kruse W, Noebels JL, Herlitze S.
    Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.
    J Neurosci 31, 4311-4326 (2011)
  • Gutierrez DV, Mark MD, Masseck O, Maejima T, Kuckelsberg D, Hyde RA, Krause M, Kruse W, Herlitze S.
    Optogenetic control of motor coordination by Gi/o protein-coupled vertebrate rhodopsin in cerebellar Purkinje cells.
    J Biol Chem 286, 25848-25858 (2011)
  • Oh E, Maejima T, Liu C, Deneris E, Herlitze S.
    Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor.
    J Biol Chem 285, 30825-30836 (2010)
  • Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES.
    Pet-1 is required across different stages of life to regulate serotonergic function.
    Nat Neurosci 13, 1190-1198 (2010)
  • Hashimotodani Y, Ohno-Shosaku T, Maejima T, Fukami K, Kano M.
    Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release.
    Neuropharmacology 54, 58-67 (2008)
  • Sato S, Hanada R, Kimura A, Abe T, Matsumoto T, Iwasaki M, Inose H, Ida T, Mieda M, Takeuchi Y, Fukumoto S, Fujita T, Kato S, Kangawa K, Kojima M, Shinomiya K, Takeda S.
    Central control of bone remodeling by neuromedin U. Nat Med 13, 1234-1240 (2007)
  • Aoki M, Mieda M, Ikeda T, Hamada Y, Nakamura H, Okamoto H.
    R-spondin3 is required for mouse placental development.
    Dev Biol 301, 218-226 (2007)
  • Mieda M, Williams SC, Richardson JA, Tanaka K, Yanagisawa M.
    The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker.
    Proc Natl Acad Sci USA 103, 12150-12155 (2006)
  • Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T, Ogawa M, Obata K, Watanabe M, Hashikawa T, Tanaka K.
    Indispensability of the glutamate transporters GLAST and GLT1 to brain development.
    Proc Natl Acad Sci USA 103, 12161-12166 (2006)
  • Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T, Kano M.
    The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum.
    J Neurosci 26, 2991-3001 (2006)
  • Maejima T, Oka S, Hashimotodani Y, Ohno-Shosaku T, Aiba A, Wu D, Waku K, Sugiura T, Kano M.
    Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum.
    J Neurosci 25, 6826-6835 (2005)
  • Hashimotodani Y, Ohno-Shosaku T, Tsubokawa H, Ogata H, Emoto K, Maejima T, Araishi K, Shin HS, Kano M.
    Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal.
    Neuron 45, 257-268 (2005)
  • Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M.
    Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice.
    Proc Natl Acad Sci U S A 101, 4649-4654 (2004)
  • Mieda M, Williams SC, Sinton CM, Richardson JA, Sakurai T, Yanagisawa M.
    Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness.
    J Neurosci 24, 10493-10501 (2004)
  • Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, Yanagisawa M, Sakurai T.
    Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
    Neuron 38, 701-713 (2003)
  • Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ, DiLeone RJ.
    Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal.
    J Neurosci 23, 3106-3111 (2003)
  • Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M.
    The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells.
    J Neurosci 22, 1690-1697 (2002)
  • Ohno-Shosaku T, Maejima T, Kano M.
    Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals.
    Neuron 29, 729-738 (2001)
  • Maejima T, Ohno-Shosaku T, Kano M.
    Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals.
    Neurosci Res 40, 205-210 (2001)
  • Maejima T, Hashimoto K, Yoshida T, Aiba A, Kano M.
    Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors.
    Neuron 31, 463-475 (2001)
  • Hirate Y, Mieda M, Harada T, Yamasu K, Okamoto H.
    Identification of ephrin-A3 and novel genes specific to the midbrain-MHB in embryonic zebrafish by ordered differential display.
    Mech Dev 107, 83-96 (2001)
  • Mieda M, Kikuchi Y, Hirate Y, Aoki M, Okamoto H.
    Compartmentalized expression of zebrafish ten-m3 and ten-m4, homologues of the Drosophila ten(m)/odd Oz gene, in the central nervous system.
    Mech Dev 87, 223-227 (1999)
  • Mieda M, Haga T, Saffen DW.
    Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1.
    J Biol Chem 272, 5854-5860 (1997)
  • Mieda M, Haga T, Saffen DW.
    Promoter region of the rat m4 muscarinic acetylcholine receptor gene contains a cell type-specific silencer element.
    J Biol Chem 271, 5177-5182 (1996)

著書・総説/Books and Reviews

  • Mieda M. The roles of orexins in sleep/wake regulation.
    Neurosci Res 118, 56-65 (2017)
  • Mieda M, Sakurai T. Orexin (Hypocretin) and Narcolepsy. In Narcolepsy, 2nd Edition: A Clinical Guide, M. Goswami, M.J. Thorpy, and S.R. Pandi-Perumal, eds. (Springer International Publishing), pp. 11-23 (2016)
  • 三枝理博, 櫻井武. オレキシンと食行動・エネルギー代謝. ねむりとマネージメント 3, 42-44 (2016)
  • 三枝理博, 櫻井武. 睡眠障害とオレキシン拮抗薬. Annual Review 糖尿病・代謝・内分泌2016, 197-205 (2016)
  • Mieda M, Sakurai T. Pharmacogenetic dissection of neural mechanisms underlying the regulation of sleep/wakefulness using DREADDs. In Designer Receptors Exclusively Activated by Designer Drugs, G. Thiel, ed. (Totowa, New Jersey: Humana Press), pp. 109-127 (2015)
  • Mieda M, Sakurai T. Physiological roles of orexin receptors on sleep/wakefulness regulation. In Orexin and Sleep - Molecular, Functional and Clinical Aspects, T. Sakurai, J.M. Monti, and S.R. Pandi-Perumal, eds. (Heidelberg, Germany: Springer International Publishing), pp. 53-65 (2015)
  • Mieda M, Ono D, Hasegawa E, Okamoto H, Honma K, Honma S, Sakurai T. Genetic dissection of neural mechanisms underlying the central circadian pacemaker. In Circadian Clocks, The proceeding volume of Sapporo Symposium on Biological Rhythm in 2014 Edited by Ken-ichi Honma and Sato Honma, Hokkaido University Press, 141-150 (2015)
  • 三枝理博. 視交叉上核のバソプレシン産生ニューロンの細胞時計はニューロンのあいだの連絡の制御をとおし行動の概日リズムを制御する. ライフサイエンス 新着論文レビュー, http://first.lifesciencedb.jp/archives/9925 (2015)
  • 三枝理博. 概日時計による睡眠の調節. 実験医学 33, 2071-2076 (2015)
  • 長谷川恵美, 三枝理博. オレキシン産生神経細胞は2つの異なる神経経路でナルコレプシーを抑制する. 実験医学 32, 1767-1770 (2014)
  • 三枝理博. オレキシンによる睡眠 ・ 覚醒調節の神経メカニズム, 金沢大学十全医学会雑誌 123, 104-108 (2014)
  • Mieda M, Tsujino N, Sakurai T. Differential roles of orexin receptors in the regulation of sleep/wakefulness. Front Endocrinol (Lausanne) 4, 57 (2013)
  • Mieda M, Sakurai T. Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status. CNS Drugs 27, 83-90 (2013)
  • Mieda M, Sakurai T. Overview of orexin/hypocretin system. Prog Brain Res 198, 5-14 (2012)
  • Sakurai T, Mieda M. Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal. Trends Pharmacol Sci 32, 451-462 (2011)
  • Sakurai T, Mieda M, Tsujino N. The orexin system: roles in sleep/wake regulation. Ann N Y Acad Sci 1200, 149-161 (2010)
  • Mieda M, Sakurai T. Integrative physiology of orexins and orexin receptors. CNS Neurol Disord Drug Targets 8, 281-295 (2009)
  • 三枝理博. 食餌同期性概日リズムの神経メカニズム. 金沢大学十全医学会雑誌 118, 51-55 (2009)
  • 三枝理博. 睡眠と摂食調節. In 睡眠学, 日本睡眠学会, ed. (東京: 朝倉書店), pp. 145-149 (2009)
  • 三枝理博, 櫻井武. オレキシン作動性システム:睡眠・覚醒、摂食、情動のインテグレーター. 細胞工学 27, 461-466 (2008)
  • Mieda M, Yanagisawa M. Rodent models of human narcolepsy-cataplexy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, S. Nisino, and T. Sakurai, eds. (Totowa, New Jersey: Humana Press), pp. 255-266 (2005)
  • Mieda M, Willie JT, Sakurai T. Rescue of narcoleptic orexin neuron-ablated mice by ectopic overexpression of orexin peptides. In The Orexin/Hypocretin System: Physiology and Pathophysiology, S. Nisino, and T. Sakurai, eds. (Totowa, New Jersey: Humana Press), pp. 359-366 (2005)
  • Mieda M, Sakurai T. History and overview of Orexin/Hypocretin research. In The Orexin/Hypocretin System: Physiology and Pathophysiology, S. Nisino, and T. Sakurai, eds. (Totowa, New Jersey: Humana Press), pp. 3-10 (2005)
  • 柳沢正史, 三枝理博. オレキシン系・その発見と個体レベルでの役割の研究. ブレインサイエンス・レビュー, 55-82 (2004)
  • Mieda M, Yanagisawa M. Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors. Curr Opin Neurobiol 12, 339-345 (2002)
  • Saffen D, Mieda M, Okamura M, Haga T. Control elements of muscarinic receptor gene expression. Life Sci 64, 479-486 (1999)
  • 三枝理博, 芳賀達也. アセチルコリン. 神経精神薬理 19 (suppl.), 79-98 (1997)
  • 三枝理博. 神経細胞特異的な遺伝子発現を制御するサイレンサー NRSE/RE1. 生化学 69, 1021-1025 (1997)
  • Saffen DW, 海老原達彦, 三枝理博. 神経活動と遺伝子発現. Mebio 1月号, 71-79 (1996)
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